Why do patients with tumor diseases suffer from cognitive deficits? This question is addressed in the work of Dr. Frederik Bartels, who has received this prestigious award for young cancer researchers in Berlin.
For more details, check out the links below to learn more about this award and Dr. Bartels’ recent work:
https://jamanetwork.com/journals/jamaoncology/fullarticle/2781389
Eines unserer Experimente zur Überprüfung der Navigationsfähigkeit zeigt hohe Sensitivität für Einschränkungen bei verschiedenen Erkrankungen, weshalb wir dieses Instrument nun möglichst vielen klinischen und Forschungseinrichtungen zur Verfügung stellen möchten.
Aufgabengebiet:
• Aufbau einer Webanwendung eines bisher in Python und auf Gorilla.sc laufenden Experiments für die Nutzung in Forschung und Klinik
• Adaptives Design für die zukünftige Integration weiterer Parallelversionen und Übersetzungen der Anwendung
• Datenspeicherung bei den Anwender*innen (direkter Download des Datensatzes zu den Ergebnissen)
• Falls möglich, Hosten der dargestellten Bilder und Videos (< 50 MB) direkt auf der Website, universitätsinterne Server existieren, sind aber noch nicht integriert
• Entwurf, Konzeptionierung der dazu erforderlichen technischen Infrastruktur, sowie Einrichtung, Implementierung der Website
Voraussetzungen:
• Durchführung/Rechnungslegung des Auftrags noch in 2022
• Ein Vertrag ist ausgeschlossen mit Personen, die bereits in einem Vertragsverhältnis zur Charité – Universitätsmedizin Berlin oder deren Töchtern stehen oder kürzlich standen (ehemaliger Arbeitnehmer/Arbeitnehmerin: 12 Monate; alle anderen: 6 Monate)
• Erstellung eines Angebots bis spätestens Ende Oktober 2022
(Berufs-)Erfahrung:
• Praktische Erfahrung auftragsbasiertem Webdevelopment
• Erfahrung in der Durchführung von ähnlichen Projekten (Referenzen)
Erwünscht:
• Erfahrung in der Umsetzung von Websites für wissenschaftliche Einrichtungen oder Kliniken von Vorteil
Bei Interesse und Fragen zum Auftrag/ Voraussetzung, kontaktiert uns gerne vorab. Weitere Informationen erteilt Carsten Finke (carsten.finke@charite.de).
We invite applications for a four-year PhD position in the CRC 1315 project “Spatial Memory Consolidation Networks”. The CRC 1315 “Memory Consolidation” brings together outstanding memory researchers from Berlin institutions, including Charité, Humboldt-Universität zu Berlin, Freie Universität Berlin and Technische Universität Berlin. The successful applicant will become a member of the Brain & Behavior Group at the Dept. of Neurology at Charité Berlin and will be embedded in an interdisciplinary network of basic and clinical neuroscience researchers. There will be continuous exchanges with Postdocs, PhD students and Faculty of the CRC and associated institutions, including the Excellence Cluster NeuroCure, the Bernstein Center for Computational Neuroscience and the Berlin School of Mind and Brain.
The project combines electrophysiological, pharmacological, imaging and lesion approaches in patients and healthy participants with behavioral/virtual reality paradigms to study contextual modulation of spatial memory consolidation.
If this sounds interesting to you, click here for more information on the project.
We invite applications for a four-year postdoctoral position in the CRC 1315 project “Spatial Memory Consolidation Networks”. The CRC 1315 “Memory Consolidation” brings together outstanding memory researchers from Berlin institutions, including Charité, Humboldt-Universität zu Berlin, Freie Universität Berlin and Technische Universität Berlin. The successful applicant will become a member of the Brain & Behavior Group at the Dept. of Neurology at Charité Berlin and will be embedded in an interdisciplinary network of basic and clinical neuroscience researchers. There will be continuous exchanges with Postdocs, PhD students and Faculty of the CRC and associated institutions, including the Excellence Cluster NeuroCure, the Bernstein Center for Computational Neuroscience and the Berlin School of Mind and Brain.
The project combines electrophysiological, pharmacological, imaging and lesion approaches in patients and healthy participants with behavioral/virtual reality paradigms to study contextual modulation of spatial memory consolidation.
If this sounds interesting to you, click here for more information on the project.
Happy to share the new preprint by Sophia and Carsten introducing: VIENNA the virtual environments navigation assessment.
New study in Annals of Neurology is Paper of the MonthOur new article on cognitive outcomes in anti-NMDAR encephalitis lead by Josephine was awarded the Paper of the Month at the Center for Stroke Research at Charité-Universitätsmedizin Berlin!
Sophia received the Penny Standen Award for Early Career Multidisciplinary Research in Disability at the “13th International Conference on Disability, Virtual Reality & Associated Technologies” (ICDVRAT) for the development of a memory independent spatial navigation paradigm (VIENNA) in a virtual reality setting. Congratulations!
Read more about her amazing work here.
The human brain is a complex network. Ever since the first description of “functional connectivity” in the 1990s, network neuroscience has emerged as one of the leading approaches to study the brain, including unparalleled international collaborations like the Human Connectome Project (HCP).
While our understanding of the connectome is rapidly increasing, some fundamental questions about brain networks remain: How does a functional connection between two brain regions form? Why are some regions more functionally connected than others? And what determines the spatial and temporal organization of the network?
In our latest preprint, we shed some light on these questions through complexity analysis of resting-state data from the HCP. In this manuscript, we report a mechanism by which the brain’s network architecture arises from spontaneous episodes of neural regularity. These episodes become visible as “complexity drops” and provide a unifying explanation for many known properties of the human brain, including functional connectivity, brain states, structure-function relationships, and network hierarchies. For more on this human “complexome”, check out the preprint!
Our recent article shows that brain-targeting autoantibodies found in lung cancer patients may be responsible for cancer-related cognitive impairment.
In this prospective, cross-sectional study we included 167 patients with lung cancer. Brain-directed autoantibodies were found in 36.5% of all patients: 19.8% had known neuronal autoantibodies and 16.8% had autoantibodies against currently unknown antigens that were detected by immunohistochemistry. Cognitive impairment was found in as much as 67.0% of patients. Importantly, patients with neuronal autoantibodies had increased odds of cognitive impairment compared with patients without autoantibodies. Interestingly, autoantibodies against currently unknown neuronal antigens were also associated with higher odds of cognitive impairment.
Therefore, our study suggests that neuronal autoantibodies might represent a pathogenic factor in cancer-related cognitive impairment among patients with lung cancer.
There is a JAMA Oncology podcast interview with Frederik and Carsten at: https://edhub.ama-assn.org/jn-learning/audio-player/18621621 and an editorial about our study at: https://jamanetwork.com/journals/jamaoncology/article-abstract/2781393
The full study can be found online here and downloaded as a pdf here!
Interested in assessing subjective memory? The German translation by @JosephineHeine and @SophiaRekers of the Multifactorial Memory Questionnaire (MMQ) is now freely available for clinicians and researchers here. Normative and psychometric data coming soon. Stay tuned!